Article
Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance.
Hepatology (Baltimore, Md.) - 1 Nov 2011
Lee Hui-Young, Birkenfeld Andreas L, Jornayvaz Francois R, Jurczak Michael J, Kanda Shoichi, Popov Violeta, Frederick David W, Zhang Dongyan, Guigni Blas, Bharadwaj Kalyani G, Choi Cheol Soo, Goldberg Ira J, Park Jae-Hak, Petersen Kitt F, Samuel Varman T, Shulman Gerald I
Abstract excerpt
UNLABELLED: Nonalcoholic fatty liver disease (NAFLD) and insulin resistance have recently been found to be associated with increased plasma concentrations of apolipoprotein CIII (APOC3) in humans carrying single nucleotide polymorphisms within the insulin response element of the APOC3 gene. To examine whether increased expression of APOC3 would predispose mice to NAFLD and hepatic insulin resistance, human APOC3...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.