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Article

MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans.

Nature - 13 Jan 2000

Ahmed S, Hodgkin J

Abstract excerpt

The germ line is an immortal cell lineage that is passed indefinitely from one generation to the next. To identify the genes that are required for germline immortality, we isolated Caenorhabditis elegans mutants with mortal germ lines--worms that can reproduce for several healthy generations but eventually become sterile. One of these mortal germline (mrt) mutants, mrt-2, exhibits progressive telomere shortening...

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Identifiers

PMID: 10646593
DOI: 10.1038/35003120

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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