Article
ACE gene D/D genotype as a risk factor for chronic nephrotoxicity from calcineurin inhibitors in liver transplant recipients.
Transplantation - 15 Feb 2006
Gallon Lorenzo, Akalin Enver, Lynch Patrick, Rothberg Laura, Parker Michele, Schiano Thomas, Abecassis Michael, Murphy Barbara
Abstract excerpt
BACKGROUND: Chronic renal failure (CRF) is a major cause of morbidity and mortality after orthotopic liver transplantation (OLTX) and is predominantly caused by calcineurin inhibitors (CI)-induced nephrotoxicity. The activation of the renin angiotensin system (RAS) has been implicated in the path...
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