Article
Association between ABCB1 (multidrug resistance transporter) genotype and post-liver transplantation renal dysfunction in patients receiving calcineurin inhibitors.
Pharmacogenetics - 1 Nov 2003
Hebert Mary F, Dowling Amy L, Gierwatowski Cynthia, Lin Yvonne S, Edwards Karen L, Davis Connie L, Marsh Christopher L, Schuetz Erin G, Thummel Kenneth E
Abstract excerpt
OBJECTIVE: Renal dysfunction is a common and costly adverse outcome of long-term treatment with calcineurin inhibitors (CNIs). We conducted a retrospective, case-control study to test whether the risk of renal dysfunction in liver transplantation patients receiving CNIs is associated with the 2677G>T transversion in exon-21 of the gene (ABCB1) encoding P-glycoprotein. A total of 120 non-Hispanic white patients...
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