Article
The role of interleukin-6 in lipopolysaccharide-induced fever by mechanisms independent of prostaglandin E2.
Endocrinology - 1 Apr 2009
Nilsberth Camilla, Elander Louise, Hamzic Namik, Norell Maria, Lönn Johanna, Engström Linda, Blomqvist Anders
Abstract excerpt
Fever has been shown to be elicited by prostaglandin E(2) (PGE(2)) binding to its receptors on thermoregulatory neurons in the anterior hypothalamus. The signals that trigger PGE(2) production are thought to include proinflammatory cytokines, such as IL-6. However, although the presence of IL-6 is critical for fever, IL-6 by itself is not or only weakly pyrogenic. Here we examined the relationship between IL-6...
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