Article
Microbial uptake in oral mucosa-draining lymph nodes leads to rapid release of cytotoxic CD8+ T cells lacking a gut-homing phenotype.
Science immunology - 24 Jun 2022
Barreto de Albuquerque Juliana, Altenburger Lukas M, Abe Jun, von Werdt Diego, Wissmann Stefanie, Martínez Magdaleno Jose, Francisco David, van Geest Geert, Ficht Xenia, Iannacone Matteo, Bruggmann Remy, Mueller Christoph, Stein Jens V
Abstract excerpt
The gastrointestinal (GI) tract constitutes an essential barrier against ingested microbes, including potential pathogens. Although immune reactions are well studied in the lower GI tract, it remains unclear how adaptive immune responses are initiated during microbial challenge of the oral mucosa (OM), the primary site of microbial encounter in the upper GI tract. Here, we identify mandibular lymph nodes...
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