Article
Class Ia MHC-deficient BALB/c mice generate CD8+ T cell-mediated protective immunity against Listeria monocytogenes infection.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2003
D'Orazio S E, Halme D G, Ploegh H L, Starnbach M N
Abstract excerpt
CD8(+) T cells are required for protective immunity against intracellular pathogens such as Listeria monocytogenes. In this study, we used class Ia MHC-deficient mice, which have a severe reduction in circulating CD8(+) T cells, to determine the protective capacity of class Ib MHC-restricted T cells during L. monocytogenes infection. The K(b-/-)D(b-/-) mutation was backcrossed onto a C.B10 (BALB/c congenic at H-2...
Topics
- Adoptive Transfer
- Animals
- CD8-Positive T-Lymphocytes
- Cell Division
- Cell Line
- Cell Separation
- Crosses, Genetic
- Cytotoxicity, Immunologic
- Epitopes, T-Lymphocyte
- Female
- H-2 Antigens
- Histocompatibility Antigen H-2D
- Immunity, Active