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Isolation of the retinoblastoma cDNA from the marine flatfish dab (Limanda limanda) and evidence of mutational alterations in liver tumors.

Environmental science & technology - 15 Dec 2005

Du Corbier Frances A, Stentiford Grant D, Lyons Brett P, Rotchell Jeanette M

Abstract excerpt

We have isolated a dab (Limanda limanda) homologue of the human retinoblastoma (Rb) tumor suppressor gene. The L. limanda partial Rb cDNA encodes a partial predicted protein of 753 amino acids. DNA sequence analysis with other vertebrate Rb sequences demonstrates that the L. limanda Rb cDNA is highly conserved in regions of functional importance. The sequence reported herein, combined with the high degree of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16475367
DOI: 10.1021/es051367c

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