Article
[Relation between mutant p53 and multidrug resistance in gastric cancer].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences - 1 Jan 2006
Xie Xin-you, Tan Ya-jun, Zhu Yong-liang
Abstract excerpt
OBJECTIVE: To explore the relationship between mutant p53 and multidrug resistance in gastric cancer. METHODS: Mutant p53 (mp53) and mp53+sv40Tag were transferred to gastric cancer cell line SGC-7901. The MDR-1 mRNA was examined using RT-PCR, and the difference in chemotherapeutic sensitivity of SGC-7901 cells with mutant p53 was compared with those with mp53+sv40Tag and controls by MTT method. RESULTS: SGC-7901...
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