Article
The role of P-glycoprotein in human gastric cancer xenografts in response to chemotherapy.
International journal of surgical investigation - 1 Jan 1999
Monden N, Abe S, Hishikawa Y, Yoshimura H, Kinugasa S, Dhar D K, Tachibana M, Nagasue N
Abstract excerpt
BACKGROUND: To clarify the contribution of P-glycoprotein (P-GP) to drug resistance of gastric cancer, the correlation between chemosensitivity of the tumor and expression of P-GP was examined using human gastric cancer xenografts in nude mice. METHODS: Two strains, P-GP-positive and -negative, were established using primary explants from patients who had not received chemotherapy. Their stable growth was...
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