Growth and differentiation of colony-forming human hepatocytes in vitro.

doi:10.1016/j.jhep.2005.10.028

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Article

Growth and differentiation of colony-forming human hepatocytes in vitro.

Journal of hepatology - 1 Apr 2006

Yamasaki Chihiro, Tateno Chise, Aratani Akio, Ohnishi Chimoto, Katayama Shigeru, Kohashi Toshihiko, Hino Hiroshi, Marusawa Hiroyuki, Asahara Toshimasa, Yoshizato Katsutoshi

Abstract excerpt

BACKGROUND/AIMS: Parenchymal hepatocytes (PHs) of rat contain colony-forming parenchymal hepatocytes (CF-PHs) as a small fraction. We aimed to demonstrate the presence of CF-PHs in humans and characterize them with respect to growth and differentiation potential. METHODS: Human PHs were co-cultured with Swiss 3T3 cells in the medium containing human serum, EGF, nicontinamide, and ascorbic acid 2-phosphate. To...

Topics

Adolescent
Aged
Albumins
Animals
Cell Differentiation
Cell Proliferation
Cells, Cultured
Child
Child, Preschool
Coculture Techniques
Culture Media

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Cytochrome P-450 Enzyme System

Female

Hepatocyte Nuclear Factor 4

Hepatocytes

Humans

Immunohistochemistry

Keratins

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PMID: 16469405
DOI: 10.1016/j.jhep.2005.10.028

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