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Article

Monoclonal MOG-reactive autoantibody from progressive EAE has the characteristics of a natural antibody.

Journal of neuroimmunology - 1 Apr 2006

Libbey Jane E, Peterson Lisa K, Tsunoda Ikuo, Fujinami Robert S

Abstract excerpt

A.SW mice sensitized with myelin oligodendrocyte glycoprotein (MOG)92-106 is an animal model for progressive multiple sclerosis (MS). We isolated MOG-reactive monoclonal antibodies that were immunoglobulin (Ig)M and polyreactive, similar to natural autoantibodies. Upon analysis of the variable (V) light chains and the diversity (D) and joining (J) regions of V heavy chains, we found they were identical to germ...

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Share to Encephalomyelitis, Autoimmune, Experimental
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16469392
DOI: 10.1016/j.jneuroim.2005.12.010

Genes

MOG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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