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Article

Monoclonal MOG-reactive autoantibody from progressive EAE has the characteristics of a natural antibody.

Journal of neuroimmunology - 1 Apr 2006

Libbey Jane E, Peterson Lisa K, Tsunoda Ikuo, Fujinami Robert S

Abstract excerpt

A.SW mice sensitized with myelin oligodendrocyte glycoprotein (MOG)92-106 is an animal model for progressive multiple sclerosis (MS). We isolated MOG-reactive monoclonal antibodies that were immunoglobulin (Ig)M and polyreactive, similar to natural autoantibodies. Upon analysis of the variable (V) light chains and the diversity (D) and joining (J) regions of V heavy chains, we found they were identical to germ...

Topics

Amino Acid Sequence
Animals
Antibodies, Monoclonal
Autoantibodies
B-Cell Activation Factor Receptor
Base Sequence
Encephalomyelitis, Autoimmune, Experimental
Genes, Immunoglobulin
Hybridomas
Immunoglobulin M

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Variable Region

Membrane Proteins

Mice

Mice, Congenic

Molecular Sequence Data

Mutation

Myelin Proteins

Myelin-Associated Glycoprotein

Source

Identifiers

PMID: 16469392
DOI: 10.1016/j.jneuroim.2005.12.010

Genes

MOG

Provenance

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