Article
A vaccinia virus lacking A10L: viral core proteins accumulate on structures derived from the endoplasmic reticulum.
Cellular microbiology - 1 Mar 2006
Rodriguez Dolores, Bárcena Montserrat, Möbius Wiebke, Schleich Sibylle, Esteban Mariano, Geerts Willie J C, Koster Abraham J, Griffiths Gareth, Locker Jacomine Krijnse
Abstract excerpt
The assembly of the intracellular mature virus (IMV) of vaccinia virus (VV), the prototype member of the poxviridae, is poorly understood and controversial. We have previously proposed that the IMV is composed of a continuous double-membraned cisterna derived from the smooth ER, whereby the genome-containing core is enwrapped by a part of this cisterna. In the present study we characterize a mutant virus in which...
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