Article
A genome-wide DNA microsatellite association screen to identify chromosomal regions harboring candidate genes in diabetic nephropathy.
Journal of the American Society of Nephrology : JASN - 1 Mar 2006
McKnight Amy Jayne, Maxwell A Peter, Sawcer Stephen, Compston Alastair, Setakis Efrosini, Patterson Chris C, Brady Hugh R, Savage David A
Abstract excerpt
In an effort to accelerate the identification of susceptibility genes in diabetic nephropathy, the first genome-wide fluorescence-based DNA microsatellite (n=6000) association screen was performed, using pools of genomic DNA derived from Irish patients with (cases; n=200) and without (controls; n=200) type 1 diabetic nephropathy. Allele image profiles were generated for 5353 (89.2%) microsatellite markers for...
Topics
- Adolescent
- Adult
- Age Distribution
- Case-Control Studies
- Child
- Chromosome Mapping
- Chromosomes, Human, Pair 10
- DNA Primers
- Diabetic Nephropathies
- Female