Article
A method for developing high-density SNP maps and its application at the type 1 angiotensin II receptor (AGTR1) locus.
Genomics - 1 Mar 2002
Antonellis Anthony, Rogus John J, Canani Luis H, Makita Yuchiro, Pezzolesi Marcus G, Nam MoonSuk, Ng Daniel, Moczulski Dariusz, Warram James H, Krolewski Andrzej S
Abstract excerpt
Evaluating the potential genetic components of complex disease will likely be aided through the use of dense polymorphism maps. Previously, we reported evidence for linkage with diabetic nephropathy on chromosome 3q in a region encompassing the type 1 angiotensin II receptor (AGTR1) gene. To further investigate any role for this gene in disease onset, we set out to design a dense polymorphism map spanning the...
Topics
- Base Sequence
- Chromosome Mapping
- Chromosomes, Human, Pair 3
- DNA Transposable Elements
- Diabetic Nephropathies
- Genetic Markers
- Humans
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Single Nucleotide
- Receptor, Angiotensin, Type 1
- Receptors, Angiotensin