Article
Genome-wide SNP genotyping study using pooled DNA to identify candidate markers mediating susceptibility to end-stage renal disease attributed to Type 1 diabetes.
Diabetic medicine : a journal of the British Diabetic Association - 1 Nov 2009
Craig D W, Millis M P, DiStefano J K
Abstract excerpt
AIMS: Genetic factors play a major role in the progression of kidney disease in diabetes. To identify candidate single nucleotide polymorphisms (SNPs) with potential effects on susceptibility to end-stage renal disease (ESRD), we performed a whole genome association scan using pooled DNA from Caucasian individuals with Type 1 diabetes. METHODS: We utilized the Illumina Infinium II HumanHap 550 beadchip platform...
Topics
- Adult
- DNA
- Diabetes Mellitus, Type 1
- Diabetic Nephropathies
- Disease Progression
- Female
- Gene Frequency
- Genetic Association Studies
- Genetic Markers
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Kidney Failure, Chronic
- Male
- Polymorphism, Single Nucleotide