Article
G protein-coupled receptors involved in GnRH regulation: molecular insights from human disease.
Molecular and cellular endocrinology - 22 Oct 2011
Noel Sekoni D, Kaiser Ursula B
Abstract excerpt
In the past two decades, an increasing body of evidence has demonstrated that several G protein-coupled receptor (GPCR)-ligand pairs are critical for normal human reproductive development and function. Patients harboring genetic insults in either the receptors or their cognate ligands have presented with reproductive disorders characterized by varying degrees of GnRH deficiency. These disorders include idiopathic...
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