Article
Haplotype analysis of UDP-glucuronocyltransferase 2B7 gene (UGT2B7) polymorphisms in healthy Japanese subjects.
Clinical biochemistry - 1 Mar 2006
Saito Katsuhiko, Moriya Hiroyuki, Sawaguchi Takeru, Hayakawa Takako, Nakahara Seiya, Goto Akira, Arimura Yoshiaki, Imai Kohzoh, Kurosawa Nahoko, Owada Eiji, Miyamoto Atsushi
Abstract excerpt
OBJECTIVES: UDP-glucuronocyltransferase 2B7 (UGT2B7) catalyzes glucuronidation of various types of endogenous compounds and drugs, but the genetic basis of interindividual variation in the metabolism of these substances has not yet been sufficiently elucidated. In addition, information about single nucleotide polymorphisms (SNPs) and haplotypes of the UGT2B7 gene that encode the enzyme in the Japanese population...
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