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Article

Nitrogen incorporation in the biosynthetic pathway of the nitrogen-containing polyketide, pamamycin in Streptomyces alboniger.

The Journal of antibiotics - 1 Nov 2005

Hashimoto Makoto, Kozone Ikuko, Kawaide Hiroshi, Abe Hiroshi, Natsume Masahiro

Abstract excerpt

The biosynthetic pathway of pamamycin (1), a nitrogen-containing polyketide, was investigated using blocked mutants of Streptomyces alboniger. Hydroxy acids K (3), L (4) and S (5) were found in cultured materials of blocked mutants and the wild type strain, but no PM-ketone (2) was detected. Hydroxy acids 3, 4, 5 and de-N-methylhydroxy acid L (7) were converted into 1, but 2 nor de-N-methylpamamycin (6) were not....

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PMID: 16466026
DOI: 10.1038/ja.2005.98

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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