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Article

Analysis of the loading and hydroxylation steps in lankamycin biosynthesis in Streptomyces rochei.

Antimicrobial agents and chemotherapy - 1 Jun 2006

Arakawa Kenji, Kodama Kazuya, Tatsuno Satoshi, Ide Sayoko, Kinashi Haruyasu

Abstract excerpt

The biosynthetic gene cluster of lankamycin (LM), a 14-member macrolide antibiotic, is encoded on the 210-kb linear plasmid pSLA2-L in Streptomyces rochei 7434AN4. LM contains a 3-hydroxy-2-butyl group at the C-13 position, which is different from an ethyl group in erythromycin. The following two possibilities could be considered for the origin of this starter moiety of LM biosynthesis: (i) an extra module exists...

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Identifiers

PMID: 16723550
DOI: 10.1128/AAC.00016-06
PMCID: PMC1479134

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Source receipt: pubmed, retrieved 7 Sept 2026.

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