Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Testing genetic association by regressing genotype over multiple phenotypes.

PloS one - 1 Jan 2014

Wang Kai

Abstract excerpt

Complex disorders are typically characterized by multiple phenotypes. Analyzing these phenotypes jointly is expected to be more powerful than dealing with one of them at a time. A recent approach (O'Reilly et al. 2012) is to regress the genotype at a SNP marker on multiple phenotypes and apply the proportional odds model. In the current research, we introduce an explicit expression for the score test statistic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Polymorphism, Single Nucleotide
Share to Algorithms
Share to Computer Simulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to Genotype

Share to Phenotype

Share to Regression Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 25221983
DOI: 10.1371/journal.pone.0106918
PMCID: PMC4164437

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Testing genetic association by regressing genotype over multiple phenotypes.PMID 25221983Read ↗

Association score testing for rare variants and binary traits in family data with shared controls.Semantic proximity Read ↗

[The application of genetic risk score in genetic studies of complex human diseases].Semantic proximity Read ↗

Partitioning gene-based variance of complex traits by gene score regression.Semantic proximity Read ↗

Partitioning gene-based variance of complex traits by gene score regressionSemantic proximity Read ↗

Rare variant association test with multiple phenotypes.Semantic proximity Read ↗

Statistical tests for detecting associations with groups of genetic variants: generalization, evaluation, and implementation.Semantic proximity Read ↗

General score tests for associations of genetic markers with disease using cases and their parents.Semantic proximity Read ↗

Allelic based gene-gene interaction in case-control studies.Semantic proximity Read ↗

A general framework for association tests with multivariate traits in large-scale genomics studies.Semantic proximity Read ↗

USAT: A Unified Score-Based Association Test for Multiple Phenotype-Genotype Analysis.Semantic proximity Read ↗

Improved power by use of a weighted score test for linkage disequilibrium mapping.Semantic proximity Read ↗

Approximate score-based testing with application to multivariate trait association analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.