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Article

New insights into growth hormone action

1 Feb 2006

Abstract excerpt

It has been 75 years since Evans and Long identified a somatic growth-promoting substance in pituitary extracts, yet it is only in the last 20 years that the molecular basis for this action has been established. Three key elements in this elucidation were the cloning of the GH receptor, the identification of Janus kinase (JAK) 2 as the receptor-associated tyrosine kinase, and the delineation of signal...

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PMID: 16461922
DOI: 10.1677/jme.1.01933

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