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Article

Silencing strategies for therapy of SOD1-mediated ALS.

Neuroscience letters - 1 Jan 2017

van Zundert Brigitte, Brown Robert H

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is an adult-onset, lethal, paralytic disorder caused by the degeneration of motor neurons. Our understanding of this disease has been greatly facilitated by studies of familial ALS caused by mutations in the gene encoding superoxide dismutase 1 (SOD1). Evidence indicates that misfolded wild-type SOD1 may also be pathogenic in sporadic ALS. Mutant SOD1 is neurotoxic through...

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Share to Amyotrophic Lateral Sclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27507699
DOI: 10.1016/j.neulet.2016.07.059

Genes

SOD1

Provenance

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