Article
Solution structure of p53 core domain: structural basis for its instability.
Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 2006
Cañadillas José Manuel Pérez, Tidow Henning, Freund Stefan M V, Rutherford Trevor J, Ang Hwee Ching, Fersht Alan R
Abstract excerpt
The 25-kDa core domain of the tumor suppressor p53 is inherently unstable and melts at just above body temperature, which makes it susceptible to oncogenic mutations that inactivate it by lowering its stability. We determined its structure in solution using state-of-the-art isotopic labeling techniques and NMR spectroscopy to complement its crystal structure. The structure was very similar to that in the crystal...
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