Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The proneural gene ascl1a is required for endocrine differentiation and cell survival in the zebrafish adenohypophysis.

Development (Cambridge, England) - 1 Mar 2006

Pogoda Hans-Martin, von der Hardt Sophia, Herzog Wiebke, Kramer Carina, Schwarz Heinz, Hammerschmidt Matthias

Abstract excerpt

Mammalian basic helix-loop-helix proteins of the achaete-scute family are proneural factors that, in addition to the central nervous system, are required for the differentiation of peripheral neurons and sensory cells, derivatives of the neural crest and placodal ectoderm. Here, in identifying the molecular nature of the pia mutation, we investigate the role of the zebrafish achaete-scute homologue ascl1a during...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Basic Helix-Loop-Helix Transcription Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endocrine System

Share to Fibroblast Growth Factor 3

Share to Microscopy, Electron

Share to Pituitary Gland, Anterior

Share to Zebrafish

Share to Zebrafish Proteins

Source

Identifiers

PMID: 16481349
DOI: 10.1242/dev.02296

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The proneural gene ascl1a is required for endocrine differentiation and cell survival in the zebrafish adenohypophysis.PMID 16481349Read ↗

Genetic analysis of adenohypophysis formation in zebrafish.Semantic proximity Read ↗

Eya1 is required for lineage-specific differentiation, but not for cell survival in the zebrafish adenohypophysis.Semantic proximity Read ↗

The bHLH transcription factor Ascl1a is essential for the specification of the intestinal secretory cells and mediates Notch signaling in the zebrafish intestine.Semantic proximity Read ↗

Zebrafish pit1 mutants lack three pituitary cell types and develop severe dwarfism.Semantic proximity Read ↗

Embryonic expression and characterization of a Ptx1 homolog in Drosophila.Semantic proximity Read ↗

Deletion of OTX2 in neural ectoderm delays anterior pituitary development.Semantic proximity Read ↗

Mash1 regulates the development of C cells in mouse thyroid glands.Semantic proximity Read ↗

Molecular and developmental mechanisms of anterior segment dysgenesis.Semantic proximity Read ↗

pitx3 defines an equivalence domain for lens and anterior pituitary placode.Semantic proximity Read ↗

Zebrafish Pax1a and Pax1b are required for pharyngeal pouch morphogenesis and ceratobranchial cartilage development.Semantic proximity Read ↗

Empty spiracles is required for the development of olfactory projection neuron circuitry in Drosophila.Semantic proximity Read ↗

Pit-1 determines cell types during development of the anterior pituitary gland. A model for transcriptional regulation of cell phenotypes in mammalian organogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.