Article
CD11b+/Gr-1+ myeloid suppressor cells cause T cell dysfunction after traumatic stress.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2006
Makarenkova Valeriya P, Bansal Vishal, Matta Benjamin M, Perez Lori Ann, Ochoa Juan B
Abstract excerpt
T cell dysfunction that occurs after surgery or trauma is associated with a poor clinical outcome. We describe that myeloid suppressor cells expressing CD11b(+)/Gr-1(+) markers invade the spleen after traumatic stress and suppress T cell function through the production of arginase 1. We created a consistent model of traumatic stress in C57BL/6 mice to perform this work. A significant number of CD11b(+)/Gr-1(+)...
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