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Article

Cutting edge: gut microenvironment promotes differentiation of a unique memory CD8 T cell population.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2006

Masopust David, Vezys Vaiva, Wherry E John, Barber Daniel L, Ahmed Rafi

Abstract excerpt

Whether tissue microenvironment influences memory CD8 T cell differentiation is unclear. We demonstrate that virus-specific intraepithelial lymphocytes in gut resemble neither central nor effector memory CD8 T cells isolated from spleen or blood. This unique phenotype arises in situ within the gut, suggesting that anatomic location plays an inductive role in the memory differentiation program. In support of this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16455963
DOI: 10.4049/jimmunol.176.4.2079

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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