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Article

Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of alpha-synuclein.

Brain pathology (Zurich, Switzerland) - 1 Jul 2003

Lauwers Erwin, Debyser Zeger, Van Dorpe Jo, De Strooper Bart, Nuttin Bart, Baekelandt Veerle

Abstract excerpt

Two mutations in alpha-synuclein, the main constituent of Lewy bodies, have been identified in familial Parkinson's disease. We have stereotactically injected lentiviral vectors encoding wild-type and A30P mutant human alpha-synuclein in different brain regions (striatum, substantia nigra, amygdala) of mice. Overexpression of alpha-synuclein induced time-dependent neuropathological changes reminiscent of Lewy...

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Identifiers

PMID: 12946025
DOI: 10.1111/j.1750-3639.2003.tb00035.x
PMCID: PMC8095986

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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