Article
Functional categorization of HLA-DRB1 alleles in rheumatoid arthritis: the protective effect.
Human immunology - 1 Oct 2003
Gibert Morgane, Balandraud Nathalie, Touinssi Mhammed, Mercier Pierre, Roudier Jean, Reviron Denis
Abstract excerpt
Because of past recombination event, human leukocyte antigen (HLA) alleles that are not closely related in overall sequence may come to resemble each other in areas coding for peptide binding regions (PBR) of HLA molecules. Peptide binding is likely to be important for the role of HLA molecules in autoimmune disease. As a result, it has been suggested that a strategy of searching for HLA disease associations that...
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