Article
Biochemical features, molecular biology and clinical relevance of the human 15-domain serine proteinase inhibitor LEKTI.
Biological chemistry - 1 Jan 2000
Walden Michael, Kreutzmann Peter, Drögemüller Katrin, John Harald, Forssmann Wolf-Georg, Hans-Jürgen Mägert
Abstract excerpt
Based on the isolation of a 55 amino acid peptide from human hemofiltrate, we cloned the cDNA for a novel human 15-domain serine proteinase inhibitor termed LEKTI. A trypsin-inhibiting activity was demonstrated for three different domains. High levels of expression of the corresponding gene were detected in oral mucosa, followed by the tonsils, parathyroid glands, thymus, and trachea. Hovnanian and coworkers...
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