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Article

Genetic structure of the Han Chinese population revealed by genome-wide SNP variation.

American journal of human genetics - 1 Dec 2009

Chen Jieming, Zheng Houfeng, Bei Jin-Xin, Sun Liangdan, Jia Wei-hua, Li Tao, Zhang Furen, Seielstad Mark, Zeng Yi-Xin, Zhang Xuejun, Liu Jianjun

Abstract excerpt

Population stratification is a potential problem for genome-wide association studies (GWAS), confounding results and causing spurious associations. Hence, understanding how allele frequencies vary across geographic regions or among subpopulations is an important prelude to analyzing GWAS data. Using over 350,000 genome-wide autosomal SNPs in over 6000 Han Chinese samples from ten provinces of China, our study...

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PMID: 19944401
DOI: 10.1016/j.ajhg.2009.10.016
PMCID: PMC2790583

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