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Article

Solutes modify a conformational transition in a membrane transport protein.

Biophysical journal - 15 Apr 2006

Kim Miyeon, Xu Qi, Fanucci Gail E, Cafiso David S

Abstract excerpt

The bacterial outer-membrane vitamin B(12) transporter, BtuB, undergoes a dramatic order-to-disorder transition in its N-terminal energy-coupling motif (Ton box) upon substrate binding. Here, site-directed spin labeling (SDSL) is used to show that a range of solutes prevents this conformational c...

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Source

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Identifiers

PMID: 16443663
DOI: 10.1529/biophysj.105.078246
PMCID: PMC1414566

Genes

SDSL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16443663-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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