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Article

Substrate-induced exposure of an energy-coupling motif of a membrane transporter.

Nature structural biology - 1 Mar 2000

Merianos H J, Cadieux N, Lin C H, Kadner R J, Cafiso D S

Abstract excerpt

BtuB is an outer membrane protein responsible for the uptake of vitamin B12 by Escherichia coli. It belongs to a family of bacterial transport proteins that derive energy for transport by coupling to the trans-periplasmic energy-coupling protein TonB. Using site-directed spin labeling and EPR we investigated the structure and substrate-induced changes in the TonB box, a highly conserved region in all TonB...

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Identifiers

PMID: 10700278
DOI: 10.1038/73309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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