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Article

Origin, antigenicity, and function of a secreted form of ORF2 in hepatitis E virus infection

18 Apr 2018

Abstract excerpt

Significance Hepatitis E virus (HEV) is a main cause of acute hepatitis worldwide. Recent evidence suggests that HEV-infected cells release a secreted form of ORF2 protein (ORF2 S ) but its origin and function are unknown. Here we demonstrate that ORF2 S and ORF2 C (the actual capsid protein) are different translation products and that ORF2 S is not essential for the HEV life cycle but inhibits antibody-mediated...

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Identifiers

PMID: 29669922
DOI: 10.1073/pnas.1721345115

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