Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

KCNQ4 mutations associated with nonsyndromic progressive sensorineural hearing loss.

Current opinion in otolaryngology & head and neck surgery - 1 Oct 2008

Nie Liping

Abstract excerpt

PURPOSE OF REVIEW: This article provides an update on the current progress in identification of KCNQ4 mutations responsible for DFNA2, a subtype of autosomal dominant nonsyndromic progressive hearing loss. RECENT FINDINGS: Hearing loss in pateints with DFNA2 usually start at high frequencies in their 20s and 30s, and then progress to more than 60 dB in less than 10 years, with middle and low frequencies often...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Disease Progression
Share to Follow-Up Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hearing Loss, Sensorineural

Share to Incidence

Share to KCNQ Potassium Channels

Share to Mutation, Missense

Share to Risk Assessment

Source

Open in PubMed Open full text

Identifiers

PMID: 18797286
DOI: 10.1097/MOO.0b013e32830f4aa3
PMCID: PMC2743278

Genes

KCNQ4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KCNQ4 mutations associated with nonsyndromic progressive sensorineural hearing loss.PMID 18797286Read ↗

A humanized murine model, demonstrating dominant progressive hearing loss caused by a novel KCNQ4 mutation (p.G228D) from a large Chinese family.Semantic proximity Read ↗

Autosomal dominant progressive sensorineural hearing loss due to a novel mutation in the KCNQ4 gene.Semantic proximity Read ↗

Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness.Semantic proximity Read ↗

A novel pore-region mutation, c.887G > A (p.G296D) in KCNQ4, causing hearing loss in a Chinese family with autosomal dominant non-syndromic deafness 2.Semantic proximity Read ↗

KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness.Semantic proximity Read ↗

A KCNQ4 c.546C>G Genetic Variant Associated with Late Onset Non-Syndromic Hearing Loss in a Taiwanese Population.Semantic proximity Read ↗

The DFNB1 subtype of autosomal recessive non-syndromic hearing impairment.Semantic proximity Read ↗

A novel KCNQ4 gene variant (c.857A>G; p.Tyr286Cys) in an extended family with non‑syndromic deafness 2A.Semantic proximity Read ↗

Novel mutation in the KCNQ4 gene in a large kindred with dominant progressive hearing loss.Semantic proximity Read ↗

Clinical and genetic features of nonsyndromic autosomal dominant sensorineural hearing loss: KCNQ4 is a gene responsible in Japanese.Semantic proximity Read ↗

Phenotypic characterization of DFNA24: prelingual progressive sensorineural hearing impairment.Semantic proximity Read ↗

Sensorineural hearing impairment: non-syndromic, recessive DFNB2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.