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Article

Impaired surface expression and conductance of the KCNQ4 channel lead to sensorineural hearing loss.

Journal of cellular and molecular medicine - 1 Jul 2013

Gao Yanhong, Yechikov Sergey, Vázquez Ana E, Chen Dongyang, Nie Liping

Abstract excerpt

KCNQ4, a voltage-gated potassium channel, plays an important role in maintaining cochlear ion homoeostasis and regulating hair cell membrane potential, both essential for normal auditory function. Mutations in the KCNQ4 gene lead to DFNA2, a subtype of autosomal dominant non-syndromic deafness that is characterized by progressive sensorineural hearing loss across all frequencies. Despite recent advances in the...

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Topics

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Share to Electrophysiology
Share to Hair Cells, Auditory

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hearing Loss, Sensorineural

Share to HSP90 Heat-Shock Proteins

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Share to Membrane Potentials

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Source

Open in PubMed Open full text

Identifiers

PMID: 23750663
DOI: 10.1111/jcmm.12080
PMCID: PMC3729637

Genes

KCNQ4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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