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Article

Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models.

The Journal of biological chemistry - 29 Mar 2013

Spitzmaul Guillermo, Tolosa Leonardo, Winkelman Beerend H J, Heidenreich Matthias, Frens Maarten A, Chabbert Christian, de Zeeuw Chris I, Jentsch Thomas J

Abstract excerpt

The function of sensory hair cells of the cochlea and vestibular organs depends on an influx of K(+) through apical mechanosensitive ion channels and its subsequent removal over their basolateral membrane. The KCNQ4 (Kv7.4) K(+) channel, which is mutated in DFNA2 human hearing loss, is expressed in the basal membrane of cochlear outer hair cells where it may mediate K(+) efflux. Like the related K(+) channel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23408425
DOI: 10.1074/jbc.M112.433383
PMCID: PMC3611004

Genes

KCNQ4
KCNQ5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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