The role of NF2 gene mutations and pathogenesis-related proteins in sporadic vestibular schwannomas in young individuals.

doi:10.1007/s11010-014-2011-9

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Article

The role of NF2 gene mutations and pathogenesis-related proteins in sporadic vestibular schwannomas in young individuals.

Molecular and cellular biochemistry - 1 Jul 2014

Chen Hongsai, Zhang Xiaoman, Zhang Zhihua, Yang Tao, Wang Zhaoyan, Wu Hao

Abstract excerpt

Vestibular schwannomas (VSs) are benign tumors arising from eighth cranial nerve and most often occur sporadically in individuals of middle age group. Sporadic VSs are rarely reported in the young population. In this study, we evaluated clinical behaviors of 12 young sporadic VSs by the statistical comparison with a matched series of 145 adult cases. We found that young tumors were characterized by an earlier...

Topics

Adolescent
Adult
Child
Female
Genes, Neurofibromatosis 2
Humans
Male
Mutation
Neuroma, Acoustic
Young Adult

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Open in PubMed

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PMID: 24619252
DOI: 10.1007/s11010-014-2011-9

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