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Article

Discordance between Etravirine Phenotype and Genotype-Based Predicted Phenotype for Subtype C HIV-1 from First-Line Antiretroviral Therapy Failures in South Africa.

Antimicrobial agents and chemotherapy - 21 Apr 2020

McCormick Kevin D, Penrose Kerri J, Brumme Chanson J, Harrigan P Richard, Viana Raquel V, Mellors John W, Parikh Urvi M, Wallis Carole L

Abstract excerpt

Etravirine (ETR) is a nonnucleoside reverse transcriptase inhibitor (NNRTI) used in treatment-experienced individuals. Genotypic resistance test-interpretation systems can predict ETR resistance; however, genotype-based algorithms are derived primarily from HIV-1 subtype B and may not accurately predict resistance in non-B subtypes. The frequency of ETR resistance among recombinant subtype C HIV-1 and the...

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Share to Anti-Retroviral Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32071061
DOI: 10.1128/AAC.02101-19
PMCID: PMC7179637

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