Article
HIV-1 protease and reverse transcriptase mutation patterns responsible for discordances between genotypic drug resistance interpretation algorithms.
Journal of acquired immune deficiency syndromes (1999) - 1 May 2003
Ravela Jaideep, Betts Bradley J, Brun-Vézinet Francoise, Vandamme Anne-Mieke, Descamps Diane, van Laethem Kristel, Smith Kate, Schapiro Jonathan M, Winslow Dean L, Reid Caroline, Shafer Robert W
Abstract excerpt
Several rules-based algorithms have been developed to interpret results of HIV-1 genotypic resistance tests. To assess the concordance of these algorithms and to identify sequences causing interalgorithm discordances, we applied four publicly available algorithms to the sequences of isolates from 2,045 individuals in northern California. Drug resistance interpretations were classified as S for susceptible, I for...
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