Characterizing the Contribution of Stem/Progenitor Cells to Tumorigenesis in the<i>Pten</i>−/−<i>TP53</i>−/− Prostate Cancer Model

Abstract excerpt

Loss of PTEN is one of the most common mutations in prostate cancer, and loss of wild-type TP53 is associated with prostate cancer progression and castrate resistance. Modeling prostate cancer in the mouse has shown that while Pten deletion in prostate epithelial cells leads to adenocarcinoma, combined loss of Pten and TP53 results in rapidly developing disease with greater tumor burden and early death. TP53...

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