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Article

The glycointeractome of serogroup B Neisseria meningitidis strain MC58.

Scientific reports - 18 Jul 2017

Mubaiwa Tsitsi D, Hartley-Tassell Lauren E, Semchenko Evgeny A, Jen Freda E-C, Srikhanta Yogitha N, Day Christopher J, Jennings Michael P, Seib Kate L

Abstract excerpt

Neisseria meningitidis express numerous virulence factors that enable it to interact with diverse microenvironments within the host, during both asymptomatic nasopharyngeal colonization and invasive disease. Many of these interactions involve bacterial or host glycans. In order to characterise the meningococcal glycointeractome, glycan arrays representative of structures found on human cells, were used as a...

Topics

Calorimetry
Gene Knockout Techniques
Glycomics
Host-Pathogen Interactions
Humans
Meningococcal Infections
Mutation
Neisseria meningitidis, Serogroup B
Polysaccharides
Surface Plasmon Resonance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virulence Factors

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Open in PubMed Open full text

Identifiers

PMID: 28720847
DOI: 10.1038/s41598-017-05894-w
PMCID: PMC5515891

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