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Article

Role of AFR1, an ABC transporter-encoding gene, in the in vivo response to fluconazole and virulence of Cryptococcus neoformans.

Infection and immunity - 1 Feb 2006

Sanguinetti Maurizio, Posteraro Brunella, La Sorda Marilena, Torelli Riccardo, Fiori Barbara, Santangelo Rosaria, Delogu Giovanni, Fadda Giovanni

Abstract excerpt

We have recently demonstrated that upregulation of the ATP binding cassette (ABC) transporter-encoding gene AFR1 in Cryptococcus neoformans is involved in the in vitro resistance to fluconazole of this yeast. In the present study, we investigated the role of AFR1 in the in vivo response to fluconazole in a mouse model of systemic cryptococcosis. Mice were infected with a wild-type fluconazole-susceptible strain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16428784
DOI: 10.1128/IAI.74.2.1352-1359.2006
PMCID: PMC1360305

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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