The ABC transporter-encoding gene<i>AFR1</i>affects the resistance of<i>Cryptococcus neoformans</i>to microglia-mediated antifungal activity by delaying phagosomal maturation

Abstract excerpt

The pathogenic yeast Cryptococcus neoformans has evolved several strategies to survive within phagocytes. Recently, it has been demonstrated that upregulation of the ATP binding cassette transporter-encoding gene antifungal resistance 1 (AFR1) is important not only for determining the resistance of C. neoformans to fluconazole but also in influencing fungal virulence. In the present study, we showed that the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antifungal resistance and susceptibility
• Share to Fungal Infections and Studies
• Share to Plant-Microbe Interactions and Immunity