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Article

Dynamic and heterogeneous mutations to fluconazole resistance in Cryptococcus neoformans.

Antimicrobial agents and chemotherapy - 1 Feb 2001

Xu J, Onyewu C, Yoell H J, Ali R Y, Vilgalys R J, Mitchell T G

Abstract excerpt

Infections with the human pathogenic basidiomycetous yeast Cryptococcus neoformans are often treated with fluconazole. Resistance to this antifungal agent has been reported. This study investigated the patterns of mutation to fluconazole resistance in C. neoformans in vitro. The MIC of fluconazole was measured for 21 strains of C. neoformans. The MICs for these 21 strains differed (0.25 to 4.0 microg/ml), but the...

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Identifiers

PMID: 11158735
DOI: 10.1128/AAC.45.2.420-427.2001
PMCID: PMC90307

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