Article
The effect of the APOE polymorphism on HDL-C concentrations depends on the cholesterol ester transfer protein gene variation in a Southern European population.
Clinica chimica acta; international journal of clinical chemistry - 1 Apr 2006
Sorlí José V, Corella Dolores, Francés Francesc, Ramírez Judith B, González José I, Guillén Marisa, Portolés Olga
Abstract excerpt
BACKGROUND: Apolipoprotein E (ApoE) locus has consistently shown a significant association with low-density lipoprotein cholesterol (LDL-C). However, its impact on high-density lipoprotein cholesterol (HDL-C) has been highly controversial suggesting that it may be context-dependent. We examined the gene-gene interaction between the common ApoE and the CETP polymorphisms in determining HDL-C concentrations in men...
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