Article
The effect of the APOE polymorphism on HDL-C concentrations depends on the cholesterol ester transfer protein gene variation in a Southern European population.
Clinica chimica acta; international journal of clinical chemistry - 1 Apr 2006
Sorlí José V, Corella Dolores, Francés Francesc, Ramírez Judith B, González José I, Guillén Marisa, Portolés Olga
Abstract excerpt
BACKGROUND: Apolipoprotein E (ApoE) locus has consistently shown a significant association with low-density lipoprotein cholesterol (LDL-C). However, its impact on high-density lipoprotein cholesterol (HDL-C) has been highly controversial suggesting that it may be context-dependent. We examined the gene-gene interaction between the common ApoE and the CETP polymorphisms in determining HDL-C concentrations in men...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Apolipoproteins E
- Carrier Proteins
- Cholesterol Ester Transfer Proteins
- Cholesterol, HDL
- Female
- Gene Frequency
- Genetic Variation
- Genotype