Article
Environmental factors modulate the effect of the APOE genetic polymorphism on plasma lipid concentrations: ecogenetic studies in a Mediterranean Spanish population.
Metabolism: clinical and experimental - 1 Aug 2001
Corella D, Guillén M, Sáiz C, Portolés O, Sabater A, Cortina S, Folch J, González J I, Ordovas J M
Abstract excerpt
To investigate APOE gene--environment interaction effects on plasma lipid concentrations, we conducted a cross-sectional study in a Mediterranean Spanish population consisting of 396 men and 513 women aged 18 to 66 years. The frequency of the epsilon 4 variant was 0.071 (95% confidence interval 0.059, 0.082), confirming the lower frequency of this allele in Southern Europe. In general, the carriers of the epsilon...
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