Differentiation of a human neuroblastoma into neuron‐like cells increases their susceptibility to transduction by herpesviral vectors

Abstract excerpt

Gene transfer is a powerful tool for functional gene analysis in human cells. In this respect, there is a need to develop experimental models that involve homogeneous cultures of human neuron-like cells susceptible to gene transduction and that are easy to handle. Here we describe an optimized and reproducible procedure to differentiate human SH-SY5Y neuroblastoma cells into a homogeneous population of...

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