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Article

Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network.

The Journal of pharmacology and experimental therapeutics - 1 May 2006

Lipecka Joanna, Norez Caroline, Bensalem Noura, Baudouin-Legros Maryvonne, Planelles Gabrielle, Becq Frédéric, Edelman Aleksander, Davezac Noélie

Abstract excerpt

The most common mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, DeltaF508, causes retention of DeltaF508-CFTR in the endoplasmic reticulum and leads to the absence of CFTR Cl(-) channels in the plasma membrane. DeltaF508-CFTR retains some Cl(-) channel activity so increased expression of DeltaF508-CFTR in the plasma membrane can restore Cl(-) secretion deficiency. Recently,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16424149
DOI: 10.1124/jpet.105.097667

Genes

CFTR
CALU

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network.PMID 16424149Read ↗

Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect.Semantic proximity Read ↗

Global proteomic approach unmasks involvement of keratins 8 and 18 in the delivery of cystic fibrosis transmembrane conductance regulator (CFTR)/deltaF508-CFTR to the plasma membrane.Semantic proximity Read ↗

Direct interaction with filamins modulates the stability and plasma membrane expression of CFTRSemantic proximity Read ↗

Local modulation of cystic fibrosis conductance regulator: cytoskeleton and compartmentalized cAMP signalling.Semantic proximity Read ↗

CFTR: a hub for kinases and crosstalk of cAMP and Ca2+.Semantic proximity Read ↗

Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects.Semantic proximity Read ↗

Resveratrol rescues cAMP-dependent anionic transport in the cystic fibrosis pancreatic cell line CFPAC1.Semantic proximity Read ↗

Intestinal cell barrier function in vitro is severely compromised by keratin 8 and 18 mutations identified in patients with inflammatory bowel disease.Semantic proximity Read ↗

SERCA pump inhibitors do not correct biosynthetic arrest of deltaF508 CFTR in cystic fibrosis.Semantic proximity Read ↗

Targeting Transgene Expression to Airway Epithelia and Submucosal Glands, Prominent Sites of Human CFTR ExpressionSemantic proximity Read ↗

Partial correction of cystic fibrosis defects with PLGA nanoparticles encapsulating curcumin.Semantic proximity Read ↗

Inhibition of protein kinase CK2 closes the CFTR Cl channel, but has no effect on the cystic fibrosis mutant deltaF508-CFTR.Semantic proximity Read ↗

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