Article
Global proteomic approach unmasks involvement of keratins 8 and 18 in the delivery of cystic fibrosis transmembrane conductance regulator (CFTR)/deltaF508-CFTR to the plasma membrane.
Proteomics - 1 Dec 2004
Davezac Noélie, Tondelier Danielle, Lipecka Joanna, Fanen Pascale, Demaugre France, Debski Janusz, Dadlez Michal, Schrattenholz André, Cahill Michael A, Edelman Aleksander
Abstract excerpt
Cystic fibrosis (CF) is a genetic disease caused by mutations in the CF gene (cftr). Physiologically, CF is characterized by an abnormal chloride secretion in epithelia due to a dysfunction of a mutated cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is a cAMP-dependent chloride...
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